" " New Nanosensor Developed to Look at Dopamine Release – Wellness for Life " "
Wellness for Life
Advertisement
  • Home
  • News
  • Family Wellness
  • Health and Wellbeing
  • Mental Wellness
  • Contact us
No Result
View All Result
  • Home
  • News
  • Family Wellness
  • Health and Wellbeing
  • Mental Wellness
  • Contact us
No Result
View All Result
Wellness for Life
No Result
View All Result
Home News

New Nanosensor Developed to Look at Dopamine Release

admin by admin
January 8, 2023
in News


“You have this new tool that now helps us make the kinds of measurements that we’ve never been able to make before, and we go into the lab and deploy this technology and we see what happens,” Beyene says. “What you see is that some really interesting phenomena begin to emerge that you haven’t even begun to think about.”

Beyene and his team use this approach with their new synthetic nanosensor designed to capture dopamine release across entire neurons with subcellular resolution. The biosensor is attached to a 2D nanofilm, dubbed DopaFilm, and neurons are then grown on top of the film.

Advertisement

When the neurons release the neurotransmitter dopamine, the chemical falls onto the film, causing it to brighten. The team then uses a custom-built microscope to capture this brightening, allowing them to visualize dopamine release from any part of the neuron and create movies to capture the chemicals as they get released and diffuse out.

Neurotransmitters that send signals between neurons are typically released from axons, the long chain coming off the neuron’s soma, or cell body. But some neurotransmitters, like dopamine, are also released from the soma and its dendrites – the tree-like structures radiating from it. While previous research demonstrated dopamine is released from the soma and dendrites, traditional methods could not provide a good enough look at exactly where or how this occurred.

Traditional biosensors use proteins targeted to the outer membrane of a neuron, allowing scientists to only observe what is happening at specific points in the cell. But Beyene’s nanosensor is immobilized across a 2D surface, allowing it to record the release of neurochemicals across an entire neuron. The sensor also exhibits extreme sensitivity to dopamine, allowing it to detect even the smallest bit of chemical signal emanating from the cells.

These characteristics allowed the team to capture the release of dopamine in unprecedented detail. The new technique enables them to obtain high-resolution images of dopamine release from axons and see for the first time the release of this important neurotransmitter from specific locations on dendrites.

Their work, reported in a new paper published in eLife, gives scientists an opportunity to take a fresh look at dopamine release from dendrites and suggests these structures may play a bigger role in brain computations than previously thought.

“We are able to create movies where we capture the full spatial and temporal extent of chemicals as they get released and diffuse, which has never been done before. And then we took advantage of that ability to study the dendritic release of dopamine, which has not been fully characterized and well understood,” Beyene says.

While the new work answers some questions, it also raises new ones, such as why some dendrites release dopamine while others are silent, Beyene says. He hopes their findings prompt new studies by neuroscientists into dopamine neurons in the brain.

“Because most tools struggle to give a good measurement and visualization of release from dendrites, the potential role of dendritic dopamine release in the bigger computation that dopamine neurons undertake has not been fully explored. Hopefully, this study will provide the impetus for researchers to take a second look,” Beyene says.

Source: Eurekalert



Source link

Tags: DopaFilmDopamine Releasehighly sensitive biosensorsNanosensorspatial resolution
Previous Post

GE HealthCare hires Kass-Hout as first CTO and more digital health hires

Next Post

20 life coach-approved questions to unlock your potential

Next Post

20 life coach-approved questions to unlock your potential

Recommended

Two Things You Never Want to Say When Someone is Upset.

December 30, 2022

Fool-Proof Baked Sweet Potato Recipe

November 24, 2022

Don't miss it

Family Wellness

Say No to Ambition | Jim Daly

January 28, 2023
Family Wellness

10 Tips on How to Begin the Camp Search

January 28, 2023
Family Wellness

How Racial Disparities Affect Outcomes

January 28, 2023
Health and Wellbeing

How To Stop Seeking Approval From Other People

January 28, 2023
Mental Wellness

A Compassion Practice for Opening the Heart

January 27, 2023
Health and Wellbeing

Perfect Steak Seasoning – Fit Foodie Finds

January 27, 2023

© 2022 Wellness For Life News Hubb All rights reserved.

Use of these names, logos, and brands does not imply endorsement unless specified. By using this site, you agree to the Privacy Policy and Terms & Conditions.

Navigate Site

  • Home
  • News
  • Family Wellness
  • Health and Wellbeing
  • Mental Wellness
  • Contact us

Newsletter Sign Up

Loading

No Result
View All Result
  • Home
  • News
  • Family Wellness
  • Health and Wellbeing
  • Mental Wellness
  • Contact us

© 2022 Wellness For Life News Hubb All rights reserved.